The Merseyside giants got the better of Bayern Munich, Porto and Barcelona in the knockout stages of this competition, and it has set up a highly-anticipated showdown with one of their domestic rivals in Madrid.
Victory for Liverpool would end Jurgen Klopp's wait for a trophy since his arrival at Anfield in October 2015 and represent the club's first piece of silverware since winning the League Cup in 2012.
Here, Sports Mole rounds up the latest injury and suspension news for Liverpool ahead of the game at Wanda Metropolitano on Saturday evening.
LIVERPOOL'S INJURY LIST
Status: Slight doubt
Type of injury: Muscular
Possible return date: June 1 (vs. Spurs)
Roberto Firmino has not featured for Liverpool since a substitute outing against Barcelona on May 1. However, Klopp recently revealed that the forward has returned to training, and the Brazilian should take his place in the starting lineup if he proves his fitness this week.
Type of injury: Thigh
Possible return date: Unknown
Naby Keita sustained a thigh injury against Barcelona at Camp Nou, and it was soon announced that the midfielder would miss the rest of the season. The Guinea international could feature at the Africa Cup of Nations next month.
LIVERPOOL'S SUSPENSION LIST
Liverpool have no suspension issues ahead of the trip to Spain.