Slade, who has not altered a first XI since mid-August, has once again refused to deviate from the winning formula which has seen the O's collect maximum points from their opening eight fixtures in League One thus far.
Meanwhile, Walsall boss Dean Smith has made two changes from last week's 1-1 draw with Rotherham.
Chelsea loanee Milan Lalkovic comes into the team at the expense of James Baxendale, while Craig Westcarr has been handed a recall for the visit to the capital, as the Saddlers look to bring an end to Orient's eight-game winning streak.
Leyton Orient: Jones; Cuthbert, Clarke, Baudry, Omozusi; Odubajo, Vincelot, James, Cox; Lisbie, Mooney
Walsall: O'Donnell; Taylor, Butler, Featherstone, Mantom; A. Chambers, Lalkovic, Downing, J. Chambers; Westcarr, Hewitt