While Leicester are currently challenging for the Premier League title, Brentford have put together a 16-match unbeaten streak in the Championship.
Leicester have dropped down to third position in the Premier League table since initially moving into top spot with victory over Chelsea on Tuesday night.
Nevertheless, Brendan Rodgers will only be focused on one match at a time, and their most recent performance against an expensively-constructed team attracted widespread plaudits.
Praise is nothing new to this Foxes side, who continue to show that they are capable of sustaining a title bid, even with the added distraction of this competition and the Europa League.
Despite having had to contend with injuries to key players, Rodgers has managed to find winning formulas, and he will have high hopes of progressing far in this competition.
Rodgers fielded a stronger-than-expected starting lineup against Stoke City in the previous round, a selection which may leave Thomas Frank in two minds regarding how to approach this match.
A number of positive coronavirus tests have left Brentford having to play catch-up in the Championship with the Bees currently possessing two games in hand on leaders Norwich City.
While Frank and his squad enjoyed a run to the EFL Cup semi-finals earlier in the season, the manager may be against using so many of his first-team players at the weekend.
Nevertheless, Brentford have defeated Southampton, West Bromwich Albion, Fulham and Newcastle United since the beginning of September, something which will have gained Rodgers's respect.
Brentford FA Cup form: W
Brentford form (all competitions): WWWLWW
Leicester City FA Cup form: W
Leicester City form (all competitions): DDWWWW
Brentford possible starting lineup:
Daniels; Dalsgaard, Pinnock, Goode, Henry; Ghoddos, Janelt, Jensen; Dervisoglu, Forss, Fosu-Henry
Leicester City possible starting lineup:
Schemichel; Pereira, Fofana, Soyuncu, Justin; Tielemans, Choudhury; Under, Perez, Barnes; Iheanacho
We say: Brentford 1-2 Leicester City
Both managers may feel inclined to make few changes for this contest, something which will only play into the favour of Leicester. We expect Brentford to make a positive impression during this contest, but the Foxes should have enough quality to edge out the in-form Championship side.