The Whites have picked up nine points from their last three fixtures to consolidate second spot in the table, while Hull have dropped into 17th position as they continue to struggle for form.
Hull continue to slide down the Championship table and are now dangerously close to the relegation zone, with just four points separating them from 21st-placed Wigan Athletic on the same number of matches.
The Tigers have still not won in the league since overcoming Sheffield Wednesday on New Year's Day, losing seven of their nine fixtures since then during a torrid run of form.
Grant McCann's side have lost their last two to Preston North End and Barnsley, meanwhile, and a home game against one of the best teams in the division is not quite what they need at this moment in time.
Hull have also only won one of their last seven matches with Leeds in all competitions, although they did record a surprise 2-0 victory at Elland Road during the 2018-19 campaign.
Between New Year's Day and February 11, Leeds only picked up one Championship win, and it would be fair to say that there was a lot of concern among the supporters that the Whites could fall away.
Marcelo Bielsa's side have responded in impressive fashion, though, winning each of their last three in the Championship, all 1-0, to consolidate second spot in the table.
As it stands, Leeds are five points clear of third-placed Fulham, while they are only four points behind leaders West Bromwich Albion, who have only lost four of their 35 league matches this season.
Bielsa's team have the best defensive record in the second tier this term with only 30 goals conceded, and Wednesday's 1-0 victory at Middlesbrough was particularly impressive as they did come under pressure.
There is still a lot of football to be played between now and the end of the season but confidence has returned at an important time for the club, who are desperate to return to the Premier League.
Hull Championship form: LDLDLL
Leeds Championship form: LLDWWW
Hull are facing another injury crisis having been hit by the news that Tom Eaves will miss the remainder of the season with an ankle issue.
Reece Burke, Jordy de Wijs and Jon Toral have also all suffered setbacks, although Mallik Wilks will be available having been ineligible against Barnsley, while Keane Lewis-Potter is also back from a hamstring problem.
As for Leeds, the main talking point surrounds the fitness of Kalvin Phillips, who did not play against Boro on Wednesday night due to a calf problem.
The midfielder is being tipped to return to the starting XI for this match, but Jean-Kevin Augustin is out with a hamstring injury, while Adam Forshaw will miss the remainder of the season following hip surgery.
Phillips for Gaetano Berardi could be the only change from the side that started at the Riverside Stadium.
Hull possible starting lineup:
Long; McKenzie, Pennington, McLoughlin, Elder; Stewart, Lopes; Irvine, Honeyman, Maddison; Magennis
Leeds possible starting lineup:
Casilla; Ayling, White, Cooper, Dallas; Costa, Klich, Phillips, Hernandez, Harrison; Bamford
We say: Hull 0-2 Leeds
It is really, really difficult to make a case for Hull in this weekend's contest. The Tigers have had a rotten 2020 thus far and will not relish facing one of the best teams in the division; we fancy Leeds to run out 2-0 winners at the KCOM Stadium in Saturday's early start.