While Lazio posted a 2-0 victory away at Cagliari, Atalanta recorded a thrilling 4-2 triumph over Torino.
Having both challenged for the Serie A title during 2019-20, Lazio and Atalanta are aware that a fast start to this campaign will keep the pressure on Juventus and Inter Milan.
Neither of last season's top two have looked particularly convincing during their opening fixtures, providing a window of opportunity for the teams who finished directly below them in the standings.
Starting their campaign later than some of their rivals, Lazio and Atalanta both got their schedules underway with victories on Saturday.
The latter found themselves involved in a chaotic encounter at Torino, going behind early before establishing a 3-2 advantage at half time.
An early goal after the break from Marten de Roon ultimately saw off the challenge of their hosts, but there was every suggestion that Gian Piero Gasperini's side may require some time to get up to speed.
Inzaghi and Gasperini will head into this encounter arguably content to settle for a draw should the opportunity arise, but collecting maximum points may act as the catalyst for a sustained bid at the league title.
Lazio Serie A form: W
Atalanta BC Serie A form: W
Barring any late fitness issues, Inzaghi could opt to name the same side which began Lazio's fixture against Cagliari.
That would leave Felipe Caicedo having to remain patient for an opportunity in the final third, while Muriqi is currently sidelined through injury.
Lazio possible starting lineup:
Strakosha; Patric, Acerbi, Radu; Lazzari, Milinkovic-Savic, Lucas, Luis Alberto, Marusic; Immobile, Correa
Atalanta BC possible starting lineup:
Sportiello; Toloi, Palomino, Sutalo; Hateboer, De Roon, Freuler, Gosens; Pasalic, Gomez; Zapata
We say: Lazio 1-2 Atalanta BC
This has all the makings of an entertaining contest, one which may be decided by a late goal. Although Atalanta have had less recovery time than their hosts, we are backing the visitors to prevail in a match which could prove pivotal come the end of the season.