AC Milan vs. Sampdoria (Saturday, 11.30am)
While both sides won just before the international break, neither was able to hold their mid-season form throughout March, with the hosts' inconsistency perhaps set to cost them their first Scudetto in a decade.
We say: AC Milan 2-1 Sampdoria
Up against a Samp side with little to play for, Milan must surely put a halt to their miserable home form with a win on Saturday.
Though the erratic visitors can be dangerous on their day, the Rossoneri's stronger motivation should prove the deciding factor, with the previously prolific front four capable of clicking into gear again before their hard-earned top four place comes into jeopardy.
Napoli vs. Crotone (Saturday, 2.00pm)
The Azzurri have won eight of their last nine home matches in all competitions, while the visitors are one of only two teams in Europe's top five leagues – along with Bundesliga outfit Schalke – yet to win away from home this season.
We say: Napoli 4-0 Crotone
Napoli have won eight of their previous nine competitive home matches and in each they have scored the opening goal before the 34th minute.
Another strong start against basement club Crotone, who are one of only two teams across the top five European leagues that have not gained a single point from losing positions this season, should steer the Azzurri towards a comfortable victory.
Genoa vs. Fiorentina (Saturday, 2.00pm)
Nineteen goals have been scored in the last four matches involving the visitors, in contrast to only eight goals scored in games involving the Rossoblu.
We say: Genoa 1-1 Fiorentina
Both Genoa and Fiorentina will feel that a victory on Saturday could be enough to ensure their Serie A status for another season.
Since the 2013-14 season, 10 of the 15 fixtures between both clubs have ended as a draw and with little to separate the two teams, we think that this encounter could finish level once again.
Benevento vs. Parma (Saturday, 2.00pm)
Having stunned Juventus in their most recent game, the home side welcome their relegation rivals to Municipal Stadium Ciro Vigorito holding a seven-point advantage over the bottom three.
We say: Benevento 1-1 Parma
With safety the target of both clubs, they face the prospect of being caught between pushing for victory and looking to avoid defeat in this game. With that in mind, we expect a tense affair, one which could end with the two sides accepting a point apiece.
Sassuolo vs. Roma (Saturday, 2.00pm)
The two teams played out a goalless draw in December's reverse fixture but have never drawn both meetings in a Serie A campaign.
We say: Sassuolo 2-2 Roma
Even though the reverse fixture between Sassuolo and Roma finished goalless in December, games involving the Neroverdi have regularly seen goals throughout this campaign.
Sassuolo's last seven home matches in Serie A have seen both teams score, and we can see this run continuing on Saturday. With injuries weakening both squads heading into this fixture, an entertaining score draw could be on the cards.
Lazio vs. Spezia (Saturday, 2.00pm)
Champions League hopefuls Lazio host Spezia at the Stadio Olimpico on Saturday afternoon, hoping to win their eighth successive home game in Serie A for the first time since 1999 under former boss Sven-Goran Eriksson.
Meanwhile, the visitors, who currently occupy 15th position in Italy's top flight, are looking to win their sixth league game since the turn of the year.
We say: Lazio 2-1 Spezia
Lazio will be keen to build on their victories over Crotone and Udinese as they bid to stay in contention for a return to European competition next season.
However, Spezia will be no pushovers on Saturday and could to make it a difficult afternoon for the hosts. Having said that, the Aquile should have enough quality, even with the absence of Alberto, to secure all three points at the Stadio Olimpico.
Atalanta vs. Udinese (Saturday, 2.00pm)
Atalanta BC hope to pick up where they left off in Serie A, as they host mid-table Udinese at the Gewiss Stadium on Saturday.
While La Dea went into the international break on a run of five wins from their last six league games to stay in the race for a top four place, their visitors this week had gone unbeaten in five before finally losing to Lazio.
We say: Atalanta BC 2-0 Udinese
The hosts' free-scoring ways are unlikely to be halted by a mere fortnight's hiatus, as they can get straight back into the groove with a win against Udinese.
As the visitors have little left to play for, it will be the Champions League-chasing Bergamaschi who are most hungry for the three points, with all of their attacking weapons available and in fine form.
Cagliari vs. Hellas Verona (Saturday, 2.00pm)
While the form of the visitors has realistically ended their bid for a top-seven spot, Cagliari's two defeats in a row have left them occupying a place in the relegation zone.
We say: Cagliari 1-1 Hellas Verona
With no wins between them since the first weekend in March, quality may be lacking during a game between two teams who are out of sorts. While the home side are under more pressure to get back on track, we feel that could inspire them to earn a positive result in their bid to avoid the drop.
Torino vs. Juventus (Saturday, 5.00pm)
With their title defence in tatters after a humbling defeat before the break, Juventus now resume the fight for a top-four place against one of their favourite opponents, as they clash with neighbours Torino in Saturday's Derby della Mole.
Beaten by Benevento last time out in Serie A, the Bianconeri return to action some ten points adrift of top spot and sorely need a bounce-back win against their fellow Turin side, who are desperate to climb away from the relegation zone.
We say: Torino 0-1 Juventus
A particularly desperate edition of the Turin Derby is set to ensue, as both sides are in danger of missing out on their objectives this season.
Even considering the mounting pressure caused by recent events on and off the field, Juventus surely have too much firepower at their disposal to let their utter dominance of Torino slip now. A hard-fought contest could well be decided by a single mistake or moment of magic in the later stages, as legs and minds start to tire.
Bologna vs. Inter Milan (Saturday, 7.45pm)
While Inter may have built a six-point lead over the chasing pack ahead of their trip to Dall'Ara, they meet hosts who ran into their best form of the season just before the break, with a third consecutive win now a possibility for Sinisa Mihajlovic's 11th-placed side.
We say: Bologna 1-2 Inter Milan
Inter's inexorable pursuit of the Scudetto is unlikely to be halted on Saturday - even by one of Serie A's in-form sides.
Having rode out the worst of a potentially debilitating COVID-19 crisis, the Nerazzurri can pick off Bologna by either lacerating them with extreme pace on the flanks or bulldozing through the centre via their potent front pairing.