Torino vs. Genoa (Saturday, 2.00pm)
The visitors are now well clear of the Serie A relegation zone following four wins from five, while the improving Granata inched above the dotted line courtesy of a remarkable comeback draw last week.
We say: Torino 2-1 Genoa
Torino's last home win in Serie A dates back to the summer - incidentally a 3-0 victory against Genoa, then coached by current Toro boss Davide Nicola.
They can finally end that winless streak on Saturday if their leaky defence are able to keep the visiting strikeforce quiet - at least to some extent. An overdue success in Turin would build on last week's fine fightback and narrow the gap to their in-form opponents.
Napoli vs. Juventus (Saturday, 5.00pm)
After their first league meeting of the season was postponed in controversial circumstances, the old rivals now clash for the second time in a matter of weeks, following Juve's Supercoppa Italiana triumph last month.
We say: Napoli 1-2 Juventus
With the scent of the Scudetto wafting nearer and nearer for in-form Juventus, there is little to suggest they cannot take advantage of their hosts' defensive woes, further widening a gap between the clubs which was non-existent only a few short weeks ago.
Pace and power out wide and penalty-box cunning through the centre should terrify Napoli's makeshift defence, with their talented forwards left with too much to do to make up the deficit.
Spezia vs. AC Milan (Saturday, 7.45pm)
Ahead of a potentially defining run of fixtures in the next month, the Rossoneri will take on Vincenzo Italiano's overachieving side at Stadio Alberto Picco following a welcome return to winning ways.
We say: Spezia 1-3 AC Milan
Not only is there a gaping gulf in stature between these two clubs, but the combination of their respective home and away records leads to only one probable outcome on Saturday.
Now nearing full availability once again, Milan can flex their range of attacking resources to flatten the plucky challenge of a spirited Spezia side and put Inter under pressure to match their result 24 hours later.