Juve have in general blown away every side in their path this season, although they have dropped points twice on the road, and are eight points clear of Lazio's city rivals Roma at the top.
Lazio's home record has kept them in the top half this season, with six wins from nine and two consecutive victories at home seeing them sit ninth currently.
In terms of personnel Lazio have a lengthy absentee list, although Senad Lulic and Ogenyi Onazi return from suspension for the clash and both Antonio Candreva and Federico Marchetti are likely to play.
For Juventus, Giorgio Chiellini is the only injury concern and is expected to miss the game.
Possible starting lineups
Lazio: Marchetti; Biava, Dias, Ciani; Cavanda, Onazi, Biglia, Lulic; Candreva; Floccari, Klose
Juventus: Buffon; Barzagli, Ogbonna, Bonucci, Peluso; Pirlo; Vidal, Isla, Marchisio; Tevez, Llorente
Sports Mole says: 1-2