Not since 1985-86 have Juventus begun a Serie A campaign with seven successive wins - a feat Napoli themselves managed last term before still only finishing second behind the dominant Turin outfit.
Victory for Juventus would leave them six points clear at the top of the table already, putting them another step closer to an unprecedented eighth successive Scudetto.
Here, Sports Mole looks at how they could line up against their closest title challengers.
Massimiliano Allegri has the personnel to switch between a number of different systems with relative ease, but a 4-3-3 looks most likely against Napoli this weekend.
Cristiano Ronaldo - now very much on the goal trail for his new club - will join Mario Mandzukic and Paulo Dybala in the attacking three once again, with Filippo Bernardeschi expected to be consigned to a place on the bench once more.
Allegri is spoilt for choice in midfield but is likely to welcome Emre Can back into the team next to Miralem Pjanic and Blaise Matuidi, meaning that Sami Khedria and Rodrigo Bentancur would miss out.