Buffon has never finished on the winning side when playing in Glasgow, while in 2001 he was on the bench as Celtic beat Juventus 4-3 in a Champions League qualifier.
The 35-year-old acknowledged that the home support could help galvanise Celtic, but played down how big an impact they could actually have.
"I have played here (Glasgow) two or three times with Parma and Juventus although the last time 10 years ago I was on the bench. It was the last match in the group and we had already qualified," said Buffon.
"The atmosphere is very British in many ways but as far as I can remember, no fan has ever scored a goal. Certainly the crowd can help Celtic but only to a certain point. The opponents can't get carried away with this and must focus on their own game.
"The most hostile atmospheres I have ever played in, I would probably have to say is Turkey, at Fenerbahce and Galatasaray. Of course, here, at both Celtic and Rangers, they have stadiums that when full have an excellent atmosphere, we already know this and we respect this very much."
The return leg between the two sides will take place on March 6.