The last-minute loss to Torino has hindered Mancini's efforts to get the Nerazzurri up the league standings as they attempt to qualify for Europe, but despite the defeat, they only sit five points adrift of sixth place.
Mancini could recall recent signing Xherdan Shaqiri after the winger only featured as a substitute last week as he continues to settle in at the club.
New teammate Lukas Podolski could be the player to drop out after making five appearances over a short space of time after sitting out the previous month at Arsenal.
Sassuolo go into the fixture having recorded just one victory in their last seven games, but that sole triumph did come at San Siro against Inter's rivals AC.
However, just two defeats have come during the same period, and although the Neroverdi have struggled for clean sheets, that record has been offset with goals in their previous nine games.
Sassuolo will overtake Inter in the league table should they win at the Mapei Stadium.
Form in Serie A: LDWDDL
Form in all competitions: DWDLDL
Possible starting lineup: Consigli, Cannavaro, Gazzola, Vrsaljko, Terranova, Brighi, Missiroli, Magnanelli, Zaza, Sansone, Berardi
Form in Serie A: WDDWDL
Form in all competitions: DDWDWL
Possible starting lineup: Handanovic, Vidic, Andreolli, D'Ambrosio, Kuzmanovic, Guarin, Obi, Kovacic, Palacio, Shaqiri, Icardi
Sports Mole says: 1-1