Inter midfielder Yuto Nagatomo will miss out due to a muscle strain that he picked up against Bologna, so Alvaro Pereira is expected to deputise. Javier Zanetti could return to the side after recovering from an Achilles injury.
Mihajlovic could name the same Sampdoria team that drew with Lazio.
Inter Milan: DWDWWD
Possible starting lineups
Inter Milan: Handanovic; Campagnaro, Rolando, Juan Jesus; Jonathan, Taider, Cambiasso, Alvarez, Pereira; Guarin; Palacio
Sampdoria: Da Costa; Palombo, Gastaldello, Costa, Mustafi; De Silvestri, Krsticic; Obiang, Wszolek, Gabbiadini; Pozzi
Sports Mole says: 2-1