After losing to Lazio in their last domestic encounter, Antonio Conte's side sit six points adrift of the league leaders, albeit with a game in hand.
However, having reached the Europa League last 16 since that setback, Inter will have regained some confidence ahead of the visit to Turin.
Here, Sports Mole predicts how the visitors could line up against Maurizio Sarri's outfit.
The most notable selection news is the return to domestic action of goalkeeper Samir Handanovic, who has now recovered from a hand injury.
While the established back three will remain the same, Ashley Young is expected to get the nod in the left wing-back position.
Although Christian Eriksen has impressed in the Europa League, the Dane has made less of an impression in Serie A, something which Conte will take into account this weekend.
Despite having completed the full 90 minutes against Ludogorets Razgrad on Thursday, Alexis Sanchez is expected to drop back down to the substitutes' bench, allowing Lautaro Martinez to partner Romelu Lukaku.