However, if the Tigers drop points, Watford could snatch the final automatic spot if they avoid defeat at home to Leeds United.
Hull will start the final day of the regular season one point ahead of Watford, but they have a far inferior goal difference than the Hornets.
Meanwhile, Cardiff should be keen to end the season on a high as they brace themselves for their first campaign in the top flight.
The home side are expected to welcome back Robert Koren following the midfielder's absence through injury for the last two weeks.
Nicky Maynard could return from the sidelines to feature on the bench for the visitors, who may also see Fraizer Campbell return.
Hull: Chester; Faye, McShane, Almohamady; Evans, Meyler, Quinn, Brady, Koren; Simpson, Boyd
Cardiff: Marshall, McNaughton, Connolly, Turner, Taylor; Conway, Gunnarsson, Mutch, Bo-Kyung; Bellamy, Helguson
Sports Mole says: 1-0