The home team, meanwhile, can play with greater freedom having picked up five points from their last three league games to move away from the relegation zone.
Indeed, despite disappointingly crashing out of the Europa League knockout stage at the first hurdle to Norwegian side Molde, Sebastian Hoeness can at least sleep easy at night almost certainly knowing his side will remain in the Bundesliga for another season.
Last weekend's 1-1 draw at Union Berlin moved Hoffenheim nine points clear of the bottom three, with only a dreadful run of form likely to see them nervously looking over their shoulders once again.
Die Kraichgauer were unfortunate not to win in Berlin, too, with makeshift centre-back Florian Grillitsch's clumsy trip in the penalty area allowing Max Kruse to score from the penalty spot and undo a very good performance from the visitors, which did at least produce a point via Nico Schlotterbeck's own goal.
Hoeness will be hoping that with greater confidence comes greater fortune after what has been a tumultuous campaign. However, his side have it all to do against a Wolfsburg side who are not even conceding goals at present, let alone losing league matches.
However, despite an incredible run of form in the Bundesliga taking Wolfsburg to third in the table and six points clear of Borussia Dortmund in fifth place, Oliver Glasner would have been disappointed by his side's 2-0 defeat at RB Leipzig in the DFP-Pokal in midweek.
That may prove no bad thing, however, with competing in the Champions League for the first time since reaching the quarter-final in the 2015-16 undoubtedly Glasner and his board's priority.
They may need to begin creating more chances again in order to get over the line, though, after a pretty fortunate 2-0 win over struggling Hertha Berlin last weekend. The hosts struggled to create anything of note until Maxence Lacroix's late header wrapped up the three points, having been gifted the opener by Lukas Klunter's own goal.
Hoffenheim Bundesliga form: WLLDWD
Hoffenheim form (all competitions): LDDWLD
Wolfsburg Bundesliga form: WWWDWW
Wolfsburg form (all competitions): WWDWWL
Hoffenheim's availability crisis shows little sign of easing, with Ishak Belfodil, Kostas Stafylidis, Mijat Gacinovic, Stefan Posch, Havard Nordtveit, Kevin Akpoguma, Dennis Geiger, Ermin Bicakcic and Benjamin Hubner all likely to be ruled out of the visit of Wolfsburg.
Glasner's only change in midweek was to bring John Brooks back into the side ahead of Pongracic, so the 46-year-old is likely to go with the same side once again.
Hoffenheim possible starting lineup:
Baumann; Vogt, Grillitsch, Richards; Kaderabek, Rudy, Samassekou, Sessegnon; Baumgartner; Kramaric, Bebou
Wolfsburg possible starting lineup:
Casteels; Mbabu, Lacroix, Brooks, Otavio; Schlager, Arnold; Baku, Gerhardt, Steffen; Weghorst
We say: Hoffenheim 1-2 Wolfsburg
We can envisage Wolfsburg grinding their way to yet another win, but perhaps at the expense of their remarkable run of clean sheets.
Kramaric and Bebou should cause them problems at times, but likewise Glasner's side may have too much going the other way against a makeshift defence.