The hosts have won just once at home in the league all season and are on a poor run of form with just four points from a possible 15.
Dortmund, who are now 10 points behind league leaders Bayern Munich, have lost three of their last four in the league and must start winning if they are to claw back the difference.
Possible starting lineups
Hoffenheim: Grahl; Beck, Sule, Vestergaard, Toljan; Firmino, Polanski, Rudy; Herdling, Modeste, Volland
Dortmund: Weidenfeller; Piszczek, Sokratis, Friedrich, Grosskreutz; Kehl, Sahin; Blaszczykowski, Mkhitaryan, Reus; Lewandowski
Sports Mole says: 1-3