Hertha, meanwhile, have taken five points from their last three matches, with the top half now in their sights.
After avoiding defeat at the unbeaten Bayer Leverkusen before dispatching city rivals Union Berlin last weekend, Hertha travelled to Borussia Monchengladbach with plenty of confidence of gaining a result on Saturday.
Bruno Labbadia's side took a surprise lead in the second half when midfielder Matteo Guendouzi, on loan from Arsenal, fired home just two minutes after the interval, but Swiss striker Breel Embolo levelled proceedings with 20 minutes remaining to see both sides leave Borussia Park with a share of the spoils with a 1-1 draw.
After losing five of their previous seven matches, Hertha now remain unbeaten from their last three fixtures, all against top-half opposition, which is exactly where Labbadia will be aiming for his side to finish this season.
A routine home win against struggling Mainz would give them a very good chance of ending matchday 12 there, with Eintracht Frankfurt just one point ahead in ninth.
Mainz certainly have no top half ambitions, though, having spent the majority of the season in the automatic relegation places. Saturday's 1-0 defeat at home to FC Koln was a devastating blow to Jan-Moritz Lichte's hopes of guiding his team to survival.
A dour first half saw Mainz have most of the possession, but struggle to create chances for top goalscorer Jean-Phillipe Mateta to convert. Elvis Rexhbecaj opened the scoring for the visitors in the second half, with Lichte's side unable to capitalise on former Norwich City loanee Ondrej Duda's red card despite having around 15 minutes remaining to find an equaliser.
Having taken five points from their previous three matches, subsequent consecutive defeats to fellow strugglers Arminia Bielefeld and Koln has seen Mainz undo all of the positive steps they had taken from those prior positive results.
However, Lichte's side remain only two points behind Arminia, so recording an upset with a win at Hertha would see them move out of the automatic relegation zone.
Hertha Berlin Bundesliga form: DWLDWD
Mainz 05 Bundesliga form: LDWDLL
Lichte will surely restore Robin Quaison to the starting XI after last season's top goalscorer was surprisingly only on the substitutes' bench against Koln.
Hertha Berlin possible starting lineup:
Schwolow; Pekarik, Boyata, Torunarigha, Plattenhardt; Stark, Guendouzi; Lukebakio, Darida, Dilrosun; Piatek
Mainz 05 possible starting lineup:
Zentner; St Juste, Hack, Niakhate; Burkardt, Latza, Fernandes, Brosinski; Quaison, Boetius; Mateta
We say: Hertha Berlin 2-1 Mainz 05
We expect Mainz to battle hard after two hugely disappointing losses in recent weeks, but ultimately Hertha should have a little too much quality for their opponents.
The hosts have looked much tougher to beat in recent weeks; providing they continue to be fully concentrated throughout, Labbadia's side can earn only their second home win of the campaign so far.