The hosts come into this one having not won any of their last three games, and they are just three points above their visitors.
Courtesy of a 2-2 draw versus Twente on Saturday, Heracles put an end to a two-game losing streak during which they failed to find the back of the net.
Ismail Azzaoui popped up with his first goal of the campaign inside the opening 10 minutes to end his side's mini-drought in front of goal and put them ahead.
Rai Vloet's 10th strike of the season put Frank Wormuth's men in front for the second time on the day but just like the first occasion, the lead was short-lived which resulted in an eventual share of the spoils.
The Heraclieden are currently 11th in the Eredivisie table, one place and three points above Saturday's opponents, who would go above them with a win.
January's reverse fixture between the teams ended in a draw, so a win here for either side puts them on top over two legs.
Zwolle ended a run of five Eredivisie games without a win in grand style, comprehensively defeating Heerenveen in a 4-1 rout.
Virgil Misidjan was the star of the show, supplying a goal and an assist as the Blauwvingers picked up a much-needed three points.
John Stegeman's men were trailing at the interval, but a remarkable second-half display ultimately turned the game on its head.
Next up for them is a trip to a ground where they won on their last visit, and following last week's victory, they will head into the game with their tails up.
Pelle Clement is back available for the away side after fully serving his suspension which he picked up as a result of his sending-off versus Groningen three Saturdays ago.
In the aforementioned game, Sai van Wermeskerken was superb for Zwolle, but that came at a personal cost as he sustained a calf injury.
On-loan Manchester City forward Slobodan Tedic is a guaranteed absentee as he continues to recover from a rib injury he suffered in a stalemate against Emmen last December.
Tim Breukers was substituted at half time in Heracles' loss to RKC Waalwijk due to a knee problem, and he remains sidelined for this one.
The home team will have to cope with the absence of Navajo Bakboord, who has not featured this season as he remains sidelined with a muscle injury.
Heracles possible starting lineup:
Blaswich; Fadiga, Propper, Rente, Quagliata; Schoofs, Azzaoui, De La Torre; Kutucu, Vloet, Burgzorg
PEC Zwolle possible starting lineup:
Zetterer; Nakayama, Van Polen, Kersten, Paal; Huiberts, Lam, Reijnders; Pherai, Buitink, Misidjan
We say: Heracles 1-1 PEC Zwolle
Heracles have stuttered in recent weeks, but they are still one of the league's most in-form teams since the turn of the year while Zwolle were on a bad run of form prior to that win last time out. On that note, we are backing a stalemate in this one, leaving the hosts above their visitors on the log.