It was the first time Germany had lost a European Championship qualifier since 2007 and Low may decide to shake up his starting lineup for the Irish visit.
As for Ireland, they hammered group minnows Gibraltar 7-0 in Dublin last night to sit just behind Poland on goal difference at the top of the pile with six points out of six.
Robbie Keane started as the only out-and-out striker against Gibraltar and scored a hat-trick inside the first 18 minutes. He should again lead the line in Gelsenkirchen and manager Martin O'Neill has little reason to make changes elsewhere.
Germany are on a 17-game unbeaten run in competitive matches at home and were also in Ireland's group for the latest World Cup qualifying fixtures in 2012 and 2013.
Possible starting lineups
Germany: Neuer; Durm, Hummels, Boateng, Rudiger; Kroos, Kramer; Draxler, Gotze, Schurrle; Muller
ROI: Forde; Meyler, O'Shea, Wilson, Ward; Hendrick, Gibson, Hoolahan, McGeady, McClean; Keane
Sports Mole says: 2-0