The Cottagers' struggle to adapt to the second tier goes on and it was Bakary Sako who gave the visitors the lead after 14 minutes.
The powerful frontman made the most of a dummy to rifle the ball home early on to give Kenny Jackett's side a great start against the Londoners.
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The lively Sako was causing problems throughout, and his inviting cross was nearly finished off by Danny Batth seven minutes before the break.
Batth against went close with a header on 77 minutes but he was unable to hit the target, and perhaps should have done better.
The result leaves the Cottagers one place from the bottom of the Championship table with zero points, while Wolves move up to ninth.