Fulham currently sit three points adrift of safety in the relegation zone in the wake of six consecutive defeats, but Meulensteen is confident that they can turn their recent fortunes around.
"I am confident because of the sort of experiences I've had for so many years at Manchester United," Meulensteen told Sky Sports News. "I know what is required at the top end of the Premier League.
"This is a different challenge with different pressure. This is making sure you realise the need to keep three teams below you.
"Don't even speak about getting into the top six, top 10, whatever it is. You need to make sure you close your ranks, and you make sure you start winning again."
Fulham host Tottenham Hotspur in the next match on Wednesday.