The Bulgarian missed last Saturday's final-minute defeat to Manchester City with a hip injury, which could also keep him out of the visit to St. Mary's.
In his absence, Mladen Petric may continue alongside Hugo Rodallega in attack, while former Greece captain Giorgos Karagounis could start for the first time since joining the Cottagers on a free transfer.
Southampton have picked up just three points so far this season and manager Nigel Adkins will have highlighted this Sunday to add to that tally when they welcome Fulham, who have been notoriously poor travellers in recent years.
Record signing Gaston Ramirez opened his Saints account against the Toffees and will provide support for the strike pair.
Southampton: Gazzaniga; Clyne, Yoshida, Fonte, Richardson; Davis, Ramirez, Chaplow, Lallana; Lambert, Rodriguez,
Fulham: Schwarzer; Riether, Hughes, Hangeland, Riise; Duff, Karagounis, Sidwell, Ruiz; Rodallega, Petric
Sports Mole says: 3-1