Streich said that Sevilla are the favourites for the group and admitted that he could look to rest one or two key players ahead of the Bundesliga clash against Eintracht Frankfurt on Sunday.
"Sevilla are favourites for the group," Bundesliga.com quotes Streich as saying. "They'll play with a crazily high tempo and press right on top of us.
"We've got lots of things to do, particularly with trying to focus on Thursday and then against Eintracht Frankfurt in the Bundesliga on Sunday, we'll see who plays."
Freiburg are currently third in Group H.