Both teams failed to win their respective league games last time out, and the game represents an opportunity to get back to winning ways.
Twente played out an entertaining 2-2 draw versus Feyenoord on Sunday, in a game where they were unlucky not to have picked up all three points.
The Tukkers missed several chances to add to that lead before it was eventually wiped out by their opponents' only shots on target.
Next up for them is a trip away from home and, given their record on the road this season, they will fancy themselves to return to De Grolsch Veste with a point at least.
Heracles lost a second consecutive league game as they were humbled at the Mandemakers Stadion, where RKC Waalwijk claimed a 3-0 win on Sunday.
However, the earlier mentioned run yielded 10 points from a possible 12, pulling the Heraclieden clear of any relegation trouble.
A repeat of last season's eighth-place finish is still achievable, but they must make up a six-point gap on Twente for that to happen.
Saturday's hosts have also won the last two meetings between the teams, and a third win in a row would be a good start to making up that deficit.
Heracles Eredivisie form: WDWWLL
FC Twente Eredivisie form: LDDLWD
Luka Ilic will miss the game as he serves the third of a three-game suspension following his sending-off at PSV Eindhoven three Saturdays ago.
The home team will have to cope with the absence of Navajo Bakboord, who has not featured this season as he remains sidelined with a muscle injury.
Heracles possible starting lineup:
Blaswich; Quagliata, Propper, Rente, Breukers; Schoofs, Azzaoui, De La Torre; Van De Water, Vloet, Burgzorg
FC Twente possible starting lineup:
Drommel; Dumic, Pierie, Pleguezuelo, Smal; Zerrouki, Roemeratoe, Bosch; Menig, Danilo, Van Leeuwen
We say: Heracles 1-2 FC Twente
The two sides are out of form at the moment so this could swing in any direction. However, we are leaning towards a Twente victory in this one albeit by a narrow margin.