The league leaders are 12 points clear of Copenhagen with two rounds of regular-season fixtures to play, while Horsens are 10th after beating the reigning champions in their last outing.
Midtjylland were in dominant form prior to the Danish top flight's coronavirus-enforced shutdown, winning 12 of their last 13 matches - the exception being a 3-1 loss to Aarhus.
What makes that run all the more remarkable is that they did not concede in any of their four games after the winter break.
Little did last season's runners-up realise then, though, was that it would be close to three months before they were next in competitive action.
Brian Priske will be hoping that his side can hit the ground running, with just two more matches to play in the regular season - at home to Horsens and away at Nordsjaelland.
Midtjylland moved above Copenhagen into top spot on matchweek eight and have stayed there ever since, the gap only widening following a shock loss for the reigning champions last time out.
Despite that impressive win a couple of months back, however, Horsens cannot finish any higher than eighth, meaning that they will contest in the relegation round.
Points carry over from the regular season, so the Yellow Danger will be looking to at least climb a couple of places over the next week or so.
Getting any points on the board on Monday will be a huge ask, though, as they have lost six and drawn three of their last 10 away league matches.
Midtjylland's Superliga form: WLWWWW
Horsens' Superliga form: DWLLLW
Head To Head
Midtjylland won the reverse fixture 2-0 in August through a couple of goals from Sory Kaba either side of half time.
That extended the Wolves' winning streak against Horsens to 12 matches, each of those coming in the league in a run stretching back to a 2-2 draw in July 2012.
We say: FC Midtjylland 2-0 AC Horsens
Horsens beat reigning champions Copenhagen in their most recent match, but Midtjylland have been on a different level to the rest of the division this term. Even accounting for the extended hiatus, the hosts will be confident of stretching their winning run in this fixture.