The encounter at St Mary's would be only the 31-year-old's third start of the league campaign, but Martinez is convinced that the veteran's experience can aid his side's Champions League qualification ambitions.
He told the Liverpool Echo: "I think Antolin's biggest strength is his mentality. I've seen him many times playing for Paraguay in the worst possible circumstances against the best strikers in world football and he's been able to cope with that with ease.
"He has incredible composure on the ball. I've seen him face Brazilians in the Copa Libertadores. I've seen him score against Italy in the 2010 World Cup which got his country a 1-1 draw.
"He reads the game well, understands the play and he's outstanding in the air. Then he's good in one versus one scenarios so as a defender he has a real advantage on strikers because of those attributes."
The Merseysiders can move into the top-four with a win over the Saints, kickoff for which is scheduled for 12.45pm.