The Colombia international was not involved in his side's goalless draw with Aston Villa on Thursday due to a calf problem, but head coach Carlo Ancelotti is hopeful that the attacker will be back in the first XI here.
Ancelotti is expected to resist the temptation to shuffle his pack following the clash with Villa, meaning that there might only be one change to the side, with Rodriguez coming in for Seamus Coleman.
The same back four are likely to take to the field once again, though, with Dominic Calvert-Lewin and Richarlison featuring in the final third of the field for Everton, who are currently eighth in the Premier League table.
There will be no Jean-Philippe Gbamin for the Toffees this weekend, though, with the midfielder out for the remainder of the season with a knee problem.
Everton possible starting lineup: Pickford; Holgate, Keane, Godfrey, Digne; Rodriguez, Doucoure, Allan, Sigurdsson; Richarlison, Calvert-Lewin
> Click here to see how Sheffield United could line up for this contest Watch the Sports Mole Football Shorts prediction for this game below:
Watch the Sports Mole Football Shorts prediction for this game below: