The Three Lions have gone five matches without defeat, winning four of those and keeping a clean sheet in each, while Wales' streak without defeat spans eight games.
Not for the first time when it comes to England duty, the talk ahead of this friendly match has been overshadowed by events off the pitch.
Gareth Southgate will be glad to have some football to discuss, although a far brighter performance will be required on the back of last month's stalemate in Denmark.
A block on the line in the dying stages denied Harry Kane in the best of the chances in a dreary deadlock, though it did at least extend England's unbeaten run without conceding.
It was the Three Lions' sixth goalless draw in 43 matches under Southgate - as many as Roy Hodgson played out in 56 games in charge.
Southgate will rightly point out, though, that his side won their previous four games by an aggregate scoreline of 18-0.
Wales' form has been even better on the results front, however, having last tasted defeat in June 2019.
Since that loss to Hungary, which appeared to have completely derailed their Euro 2020 bid, Ryan Giggs's men have won six and drawn two.
That includes four wins in a row without conceding, most recently seeing off Finland and Bulgaria by the same 1-0 scoreline last month in the UEFA Nations League.
Both sides have a double-header of Nations League fixtures to come over the next week and will undoubtedly prioritise those games.
However, this is a derby clash and, while fans will not be in attendance, neither manager will want their respective unbeaten runs to end at the hands of their neighbouring nation.
It was England supporters celebrating when the sides last met in a memorable Euro 2016 group clash four years ago, with a late Daniel Sturridge strike making it five wins in a row for the Three Lions in this fixture.
England form (all competitions): LWWWWD
Wales form (all competitions): DDWWWW
Greenwood and Foden have been left out of the squad after last month's antics, while Chilwell, Sancho and Abraham are unlikely to feature in this first of three games in six days.
England possible starting lineup:
D.Henderson; Alexander-Arnold, Gomez, Mings, Saka; Rice, J.Henderson; Barnes, Grealish, Rashford; Calvert-Lewin
Wales possible starting lineup:
Hennessey; N.Williams, Mepham, Ampadu, Davies; Smith, Morrell; Brooks, J.Williams, James; Moore
We say: England 1-0 Wales
Wales have been in fantastic form over the past 18 months or so but, without his two best players, this will be a massive task for Giggs.
England have won five in a row against the Dragons since 1984 and we are expecting that run to go on for a little while longer.