Since taking charge, Rooney has led his Derby side to four draws and one win in his first five games, which will surely be viewed as footsteps in the right direction for Derby fans who have watched their side struggle for the majority of the season so far.
The Rams' defensive record has seen a vast improvement, and this fixture will be an opportunity for them to keep their fourth straight clean sheet for the first time since February 2018.
Rooney and his players will also be buoyed by the fact that Derby have not lost to Swansea in their last six matches, consisting of three wins and three draws.
Swansea currently sit third in the table, four points adrift of leaders Norwich City, after claiming three wins and only one loss from their last five fixtures.
Steve Cooper and his men left Cardiff with a win and the bragging rights, securing an important victory over their South Wales rivals that will no doubt lift the city's mood.
As mentioned, Swansea's form against their midweek opponents is not the strongest, with only one win in their last eight away league games against Derby, winning 1-0 in February 2010 under Paulo Sousa.
Much like Derby, Swansea have relied on their defensive strengths to see them through. The Welsh side have not conceded more than twice in any of their last 31 league games since a 4-4 away draw at Hull in February, conceding just 22 goals across those 31 matches.
At the other end, Cooper will be hoping that Jamal Lowe can build on his brace against Cardiff, after he went without a goal in the 10 games prior to the derby.
Derby County Championship form: LDDWDD
Swansea City Championship form: DWLWDW
Graeme Shinnie should return to the starting lineup for Derby, after serving a one-match suspension.
Curtis Davies will likely miss out after suffering an Achilles injury against Brentford last Wednesday.
For the Swans, defender Tivonge Rushesha is set to miss the rest of the season because of a cruciate ligament injury.
On-loan Wolves midfielder Morgan Gibbs-White is close to returning to training after two months out with a foot problem but will not be available on Wednesday night.
Derby County possible starting lineup:
Marshall; McDonald, Wisdom, Clarke, Forsyth; Bielik, Shinnie; Lawrence, Knight, Jozwiak; Kazim-Richards
Swansea City possible starting lineup:
Woodman; Naughton, Cabango, Latibeaudiere; Roberts, Smith, Grimes, Bidwell; Dhanda; Ayew, Lowe
We say: Derby County 1-2 Swansea City
Cooper spoke of Swansea reaching the peak of their powers against Cardiff on Saturday, and we expect them to continue that form against a Derby side still struggling for rhythm. We expect the Swans to prove too strong for Rooney's men, taking all three points back to Wales.