Meanwhile, Gary Rowett's side head to Pride Park having won their last two visits there by a 1-0 scoreline.
After a run of four matches without a win, including Wednesday night's goalless draw away at Barnsley, Wayne Rooney and his Derby squad will be looking over their shoulder at the possibility of a relegation scrap.
The Rams are currently seven points clear of the bottom three, although 22nd-placed Rotherham United have three games in hand.
Rooney's side have a challenging run ahead for the rest of this campaign, with Sheffield Wednesday on the final day of the season their only opponent who sit below 15th position.
On home soil, Derby have improved defensively in recent weeks, shipping just four goals in their last nine games at Pride Park, prior to conceding 13 times in their first eight home league matches in 2020-21.
Victory on Saturday would be their first of the month and could move them up one place above rivals Nottingham Forest into 17th position.
Millwall suffered their fourth home league defeat of the season as they were beaten 2-0 by Blackburn Rovers last weekend.
The result has seen Rowett's side slip down to 11th in the table, 12 points behind the playoffs and 14 points clear of the relegation zone.
Millwall head to Pride Park with the seventh-best away record in the division, accumulating a total of 24 points from their 17 games on the road.
The Lions lost last time out against Derby as Jason Knight's effort was enough to seal a slender 1-0 victory for the Rams in early December. Rowett has also lost his last two meetings with his former club and will be hoping to avoid another defeat on Saturday.
After failing to score in their last three matches, Derby manager Rooney may decide to name Martyn Waghorn in his starting lineup alongside top goalscorer Colin Kazim-Richards, which could see Lee Gregory drop to the bench against his former club.
Winger Kamil Jozwiak, who has found the net just once in 31 league appearances this season, could make way for new recruit Patrick Roberts, on loan from Manchester City, who was an unused substitute against Barnsley.
Millwall boss Rowett is unlikely to make too many changes from his starting lineup, despite losing against Blackburn last weekend.
Derby County possible starting lineup:
Roos; Byrne, Wisdom, Clarke, Buchanan; Bird, Shinnie, Knight; Waghorn, Roberts; Kazim-Richards
Millwall possible starting lineup:
Bialkowski; Evans, Hutchinson, Cooper; Romeo, Woods, Thompson, Malone; Wallace, Bodvarsson, Bennett
We say: Derby County 0-0 Millwall
Both Derby and Millwall will be keen to address their current form and get back to winning ways on Saturday.
The hosts are yet to score in March and will be looking to find their shooting boots against a Lions outfit that have conceded in each of their last four matches; with little to separate the two teams, we can see a draw being played out at Pride Park.