Bournemouth vs. Stoke (Saturday, 12.30pm)
In sharp contrast, the Potters head into the contest at the Vitality Stadium keen to avoid dropping down to 15th spot after a dismal second half of the campaign.
We say: Bournemouth 2-1 Stoke City
Having rested players last weekend, Bournemouth could have a more familiar look to them at the weekend. While we do not expect them to be firing on all cylinders, the Cherries should have enough to claim the three points.
Barnsley vs. Norwich (Saturday, 12.30pm)
The Canaries will play Premier League football next season while the Tykes are aiming to join them as they prepare for the playoffs.
We say: Barnsley 1-0 Norwich City
Norwich's intensity dropped after they won promotion, and it may be the same now they have secured the title. If Farke rotates as expected, then we think Barnsley will earn the points in this one, particularly as the Tykes will be eager to head into the playoffs with a win under their belts.
Blackburn vs. Birmingham (Saturday, 12.30pm)
This will be the fifth time that the Blues have faced the Rovers on the final day of a league season, and they have yet to lose against them, winning and drawing two games each.
We say: Blackburn Rovers 2-1 Birmingham City
Both Blackburn and Birmingham can enjoy the final day of the season, with no pressure riding on the result.
The hosts are more likely to field a stronger side than their opponents and that could help them claim all three points at Ewood Park this weekend.
Bristol City vs. Brentford (Saturday, 12.30pm)
Meanwhile, their hosts are happy that the season is coming to an end having dropped down to 19th place, a consequence of three successive defeats.
We say: Bristol City 1-2 Brentford
With both teams potentially making alterations, we expect this contest to be closer than many are predicting. Nevertheless, the Bees will want to maintain their momentum, and they could edge this contest by the odd goal in three.
Cardiff vs. Rotherham (Saturday, 12.30pm)
The Millers are winless in seven, but that has to change in South Wales against a Cardiff side looking to finish a mixed campaign in seventh place.
We say: Cardiff City 2-0 Rotherham United
Rotherham are fighting for their lives and need to win at the Cardiff City Stadium to have any hope of staying up at the expense of Derby.
With the pressure off, Cardiff have won two games in a row - scoring six times in the process - and we can see the Bluebirds relegating their opponents here.
Coventry vs. Millwall (Saturday, 12.30pm)
We say: Coventry City 1-2 Millwall
Millwall returned to winning ways last time out and will be keen to finish as high up the table as possible.
Given the points gap between the teams, and the recent record of the away side in this fixture, we are backing the Lions to grind out a narrow victory.
Derby vs. Sheff Weds (Saturday, 12.30pm)
Two Championship teams looking to avoid relegation will lock horns on the final day of the season as Derby County face Sheffield Wednesday for what is set to be a captivating encounter at Pride Park on Saturday.
At least one of these two clubs will be relegated to League One with a victory for the Rams guaranteeing their survival, while the Owls need to claim all three points and hope that Rotherham United fail to win away at Cardiff City.
We say: Derby County 1-2 Sheffield Wednesday
With Championship football at stake, immense pressure will be on both Derby and Sheffield Wednesday and Saturday's encounter is set to have plenty of drama and tension, along with a few tears of joy or sadness, depending on the result.
Taking into account their miserable run of form, it is hard to see the Rams claiming any points at present and even though the Owls have such a poor away record of their own this campaign, we can see the visitors securing all three points, which would see them climb to safety if Rotherham fail to win.
Middlesbrough vs. Wycombe (Saturday, 12.30pm)
While Boro are unbeaten in their last three outings, they can realistically only finish as high as ninth position with success at the Riverside Stadium.
We say: Middlesbrough 1-1 Wycombe Wanderers
While Wanderers will inevitably push for goals, they cannot afford to concede during the early stages. If Boro can keep the visitors out in the first half, we expect this contest to peter out into an uneventful draw.
Nott'm Forest vs. Preston (Saturday, 12.30pm)
After top-10 finishes last year, both sides have worried about the threat of relegation for portions of this campaign and will each end in the bottom half.
We say: Nottingham Forest 0-1 Preston North End
Recent form may set the precedent for the result of this game as the season draws to a close. Forest look as if they hit the beach weeks ago, while Preston are finishing with a flourish, and we expect the Lilywhites to claim victory.
QPR vs. Luton (Saturday, 12.30pm)
The two sides have secured top half finishes – QPR in ninth and Luton in 12th – and are heading into the summer in good form.
We say: Queens Park Rangers 1-0 Luton Town
This is a hard one to predict as both sides will want to end strong seasons with victories, but we are backing QPR as Luton played in midweek and looked slightly fatigued against Rotherham. That said, the Hatters have surprised people all season, so they may pull out another rabbit on Saturday.
Reading vs. Huddersfield (Saturday, 12.30pm)
Reading and Huddersfield Town meet at the Madejski Stadium on Saturday afternoon looking to end a disappointing campaign on a high.
While the Royals will still want to finish in seventh position after losing out in the Championship playoff race, Huddersfield can finish in 20th spot if they claim all three points.
We say: Reading 3-1 Huddersfield Town
After a long season, some first-team regulars could be handed the weekend off by both managers. Nevertheless, we still expect Reading to make light work of their opponents, showcasing their extra firepower in the final third.
Watford vs. Swansea (Saturday, 12.30pm)
The Hornets have secured an instant return to the Premier League as runners-up in the second tier and the Welsh side will be hoping to join them.
We say: Watford 1-1 Swansea City
This game looked like it might be a promotion-decider a few weeks ago, but with Watford over the line and Swansea now focused on the playoffs, both teams might play it fairly safe – particularly with the Hornets depleted through injuries and the Swans monitoring several players. We think that it will end all square.