Two new managers face off at Selhurst Park on Tuesday with their clubs enduring contrasting fortunes at either end of the table.
Palace will be confident of a win as they are unbeaten in 12, a run stretching back to the end of August, and are just a point off the top of the league.
Ipswich, meanwhile, are still four points from safety despite Saturday's win at St. Andrews.
Holloway is likely to continue with a winning XI that includes the division's second-top scorer Glenn Murray, while McCarthy could ring the changes after some of his loan players looked tired in the closing stages against Birmingham.
Jay Emmanuel-Thomas could be in line for a recall to the starting lineup after missing out on Saturday.
Possible starting lineups:
Palace: Speroni; Ward, Ramage, Delaney, Parr; Jedinak, Dikgacoi; Bolasie, Garvan, Zaha; Murray
Ipswich: Henderson; Edwards, Chambers, Higginbotham, Cresswell; Reo-Coker, Wellens; Emmanuel-Thomas, Martin; Murphy, Campbell
Sports Mole says: 2-1