Manager Ian Holloway has overseen back-to-back victories for his Eagles side and he will be hoping that they can continue that run against Derby.
Holloway will have to decide whether to rest star player Wilfried Zaha after his international debut for England created widespread media attention.
Derby fell to a narrow 2-1 defeat against Millwall last weekend to prevent them from earning their third victory in a row.
Manager Nigel Clough insisted that he thought his side deserved at least a point in that game, so he could retain the same team against the Championship leaders.
Crystal Palace: DDWWWW
Derby County: DWLWWL
Possible starting lineups:
Crystal Palace: Speroni; Ward, Delaney, Ramage, Parr; Bolasie, Dikgacoi, Garvan, Jedinak, Zaha; Murray
Derby County: Legzdins; Brayford, Roberts, Keogh, O'Connor; Bryson, Coutts, Hendrick, Hughes; Robinson, Sammon
Sports Mole says: 3-1