Colchester United will look to start their League One campaign as they finished the last, with a home victory.
However, they entertain a Blackpool side who endured a nightmare season that saw them drop out of the Championship and with the fans at loggerheads with the club's hierarchy over their running of the Tangerines in recent years.
The U's retained their League One status in dramatic fashion with a final-day victory over Preston North End.
United's late-season form helped set up that last-day escape, with the Essex club taking eight points from a possible 12 to finish.
New recruits from around League One may see the Blues dodge another fight for survival, but recent history suggests that United are perennial strugglers in the division.
The U's have finished in the bottom half in each of the last three seasons and two of those campaigns have seen the team narrowly avoid relegation.
Recent form: LLDWDW
The fact that the club were relegated by some distance might, in any other season, prove to be the biggest talking point for Blackpool fans, but events off the pitch have overshadowed their team's plight.
The Tangerines' last game of the fateful Championship campaign, which saw them finish bottom of the table, was abandoned after fans invaded the pitch at Bloomfield Road.
However, the lack of football appeared to be the last thing on the minds of supporters, who occupied the centre circle to vent their frustration at chairman Karl Oyston, with one masked spectator even trying to break into the director's box.
Days before that abandoned fixture, the club were criticised for removing a statue of Blackpool hero Stan Mortensen from outside the stadium, reportedly in a bid to take away a focal point for protesters.
During pre-season, fans invaded the centre circle again during a friendly at Lancaster City, which inevitably led to the match being called off.
The ongoing stand-off may not be good for the club's league fortunes, with a suspended three-point deduction hanging over them for that Huddersfield abandonment, but they will be looking to arrest a woeful away run, having failed to win on their travels through the 2014-15 season.
However, a narrow defeat at Cardiff City as well draws against Ipswich Town and Reading in the run-in may, at least, give Blackpool hope of rediscovering their form when they resume life in the third tier.
Recent form: DDLLLL
Ambrose could make his Colchester debut, having had a full pre-season to prove his fitness at Ipswich ahead of the start of this campaign.
The Tangerines have new signings of their own, with Emmerson Boyce leaving Wigan Athletic after nine years, and the defender could make his competitive debut for the club.
Colchester United possible starting lineup:
Parish, Brindley, Kent, Wynter, Vincent-Young; Ambrose, Edwards, Moncur; Massey, Porter, Bonne
Blackpool possible starting lineup:
Doyle, Boyce, Jones, Robertson, Ferguson, Osayi-Samuel, Potts, McAlister, Cameron, Redshaw, Cullen
Head To Head
One crumb of comfort for travelling Tangerines fans is Blackpool's record against Colchester, having lost only once away from home against the U's in more than 31 years.
In that period, there have been 10 draws between the sides, and the Fylde club have won only three at Colchester's old Layer Road ground, with the last meeting coming in December 2007.
We say: Colchester United 1-0 Blackpool
The bookmakers have Blackpool as the outsiders in this one and it is hard to disagree with them at the best of times, let alone after the last 12 months the Tangerines have endured. The experience of Boyce at the back could help settle the much-troubled club down on the pitch. That said, we've gone for a narrow United victory.