However, the Latics are looking for a third win in four games as they try to get their bid for promotion back to the Championship in full swing.
Despite losing manager Paul Cook after losing their playoff semi-final to Preston North End last season, the Spireites look to be mounting another push for a top-six place.
Dean Saunders took charge of Chesterfield over the summer and saw his side get off to a winning start against Barnsley.
Chesterfield did manage to return to winning ways against Shrewsbury Town and, despite drawing 0-0 at home to Rochdale, the Spireites beat Millwall 2-0 last weekend to leave them three points behind leaders Walsall.
Recent form: DWLWDW
Recent form (all competitions): WLLWDW
Wigan's relegation from the Championship last season capped off a difficult campaign for the 2013 FA Cup winners.
The Lancashire club's current campaign got off to a bad start with defeat away to Coventry City before losing at home to Bury in the League Cup.
A defeat away to high-flying Gillingham left Caldwell's side in mid-table, but they redeemed themselves with a hard-fought 1-0 win against Crewe Alexandra.
However, Wigan are still searching for their first points on the road this term, having lost three of their final four fixtures last season.
Recent form: LLDWLW
Recent form (all competitions): LLDWLW
Gary Caldwell could look to give Kellett and Hendry their debuts in defence against Chesterfield.
Meanwhile, Chesterfield could opt to name the same side that beat Millwall last weekend.
Chesterfield possible starting lineup:
Lee, O'Neil, Hird, Evatt, Jones, Ariyibi, Morsy, Martinez, O'Shea, Gardner, Ebanks-Blake
Wigan Athletic possible starting lineup:
O'Donnell, James, Perkins, Hendry, Power, Grigg, Vuckic, Jacobs, Kellett, Kenny, Pearce
Head To Head
Chesterfield have struggled in recent encounters with the Latics, having failed to beat Wigan in their last 10 meetings.
Wigan's last defeat against the Spireites came in a Coca Cola Cup tie back in August 1997, which featured a young Roberto Martinez in midfield for the visitors, who lost 1-0 at Saltergate.
We say: Chesterfield 1-0 Wigan
Chesterfield are slight favourites with the bookmakers to beat the Latics and their home form, combined with Wigan's record on the road, suggests that the Spireites could indeed edge this encounter.