The Blues reportedly had a £16m bid for the Brazilian rejected by the Ukrainian club in January.
However, Lucescu now seems to have given his blessing over a move.
"They have to pay the price," he told Sky Sports News. "They have to pay the price because we bring the players here at 17 or 18 years old.
"If Chelsea pay his [asking price], I am not against letting my players play for the big clubs.
"If they pay the price, he can go. If not, he will remain here because he has another two-and-a-half years on his contract."
Willian moved to Shakhtar from Corinthians in 2007 for £12m.