Morata's absence sees Eden Hazard switch to a centre-forward role, while Willian and Pedro also come into the XI as head coach Antonio Conte shuffles his pack following the 1-0 defeat at West Ham United.
As for hosts Huddersfield, head coach David Wagner has made just the one change from the team that started Saturday's 2-0 win over Brighton & Hove Albion at the John Smith's Stadium.
Huddersfield Town: Lossl; Smith, Jorgensen, Schindler, Lowe; Hogg, Mooy; Williams, Ince, Kachunga; Mounie
Subs: Coleman, Whitehead, Cranie, Van La Parra, Depoitre, Quaner, Hadergjonaj
Chelsea: Courtois; Azpilicueta, Christensen, Rudiger; Moses, Kante, Bakayoko, Alonso; Willian, Hazard, Pedro
Subs: Caballero; Cahill, Ampadu, Drinkwater, Fabregas, Musonda, Batshuayi
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