Wolves make the trip to Stamford Bridge keen to complete the double over the Blues, having prevailed at Molineux in December.
Chelsea have only won four of their last eight matches in the Premier League, but Maurizio Sarri is aware that his team could potentially return to the top four in the standings by the end of the week.
The Blues are just two points adrift of Manchester United - who face fellow rivals Arsenal on Sunday - and a draw between those two clubs and a two-goal triumph for Chelsea would leave Sarri's men ahead of both teams with a game in hand.
That scenario would see the recent doom and gloom lifted from Stamford Bridge in the short term, and it would be a welcome break for Sarri who has frequently had to field questions about his future.
Speculation has eased over the past two weeks, however, with Chelsea delivering a much-improved performance against Manchester City in the EFL Cup final before registering wins over each of Tottenham Hotspur, Fulham and Dynamo Kiev.
Chelsea were perhaps fortunate to edge out neighbours Fulham at Craven Cottage but as it stands, Sarri and his side remain on course to achieve their targets in each of the Premier League and Europa League at a crucial period of the season.
Sarri will be delighted that his backline has improved considerably in recent weeks with just four goals being conceded in seven outings, while Chelsea are also beginning to click in the final third.
That has resulted in Callum Hudson-Odoi having to remain patient on the bench, but the youngster showed in midweek that he can have a significant impact on what Chelsea achieve by the end of the season.
Recent form: LLWLWW
Recent form (all competitions): LWDWWW
There have been signs that tiredness has started to become a factor in Wolves' squad, and it comes as little surprise with Nuno Espirito Santo only using 17 outfield players in the Premier League this season.
However, Nuno discovered the benefits of making changes last weekend as Wolves produced a dominant performance against Cardiff City, and it was a result which has kept the club in seventh place in the table.
Those alterations were partly made with the FA Cup quarter-final with Manchester United in mind, but it at least reassured the Portuguese that he does not have to rely on a tried-and-tested starting lineup.
Those who were rested last weekend will return for the game in England's capital, and there will be a desire to build on a superb record away at the biggest clubs in the Premier League.
Five points have been recorded in games away at Man United, Arsenal and Tottenham Hotspur, with the emphatic defeat at Manchester City partly due to Willy Boly's early red card.
Wolves have also got the better of Chelsea this season, and Nuno will be confident of a similar result with his squad having had a much-needed break this week.
Last season's Championship winners can also head into their remaining fixtures having achieved their best-ever points total in the Premier League, but Wolves will no doubt want to end the campaign with a place in next season's Europa League.
Whether that target will stay achievable remains to be seen, but there has been every indication that Wolves have reached the stage in their development where they will not be overawed against any of their opponents.
Recent form: WWDDLW
Recent form (all competitions): WDWDLW
Sarri has a decision to make regarding Hudson-Odoi - who only featured on the bench against Dynamo Kiev - but Pedro could get the nod over the academy graduate.
Cesar Azpilicueta, Antonio Rudiger, Emerson Palmieri, N'Golo Kante, Eden Hazard and Higuain did not feature in the starting lineup against the Ukrainian giants, but each of those players should start at the weekend.
Chelsea possible starting lineup:
Arrizabalaga; Azpilicueta, Rudiger, Luiz, Palmieri; Kante, Jorginho, Barkley; Pedro, Higuain, Hazard
Wolverhampton Wanderers possible starting lineup:
Patricio; Saiss, Coady, Boly; Doherty, Dendoncker, Moutinho, Neves, Otto; Jota, Jimenez
Head To Head
Sunday's encounter will represent the 107th competitive meeting between the two clubs, with Chelsea having recorded 41 wins in comparison to 39 victories for Wolves.
However, the West Londoners have prevailed in 10 of the last 12 contests, with each of Wolves' triumphs coming in the West Midlands.
Wolves have not won at Stamford Bridge since a 1-0 success in a Division One fixture in 1974.
We say: Chelsea 3-1 Wolverhampton Wanderers
Wolves have already proven that they are capable of gaining results against the top clubs this season, but we are backing Chelsea this weekend. Sarri appears to be rotating between a tight-knit group of 20 players and while there may be a couple of alterations, it should not prevent the Blues from claiming victory.