With that advantage in mind, interim manager Rafael Benitez has been tipped to make a handful of changes to his lineup.
Chelsea can also boast good form at home in European competitions of late, having been unbeaten in the last nine outings at the Bridge. The last team to win in West London in a UEFA tournament was Manchester United back in 2011.
Meanwhile, Sparta have won in England since they overcome Watford back in 1983 - a run that dates back six matches.
Having started the first meeting on the bench, former West Bromwich Albion and Blackpool striker Roman Bednar could be drafted into the starting lineup this time around.
Possible starting lineups
Chelsea: Cech; Azpilicueta, Terry, Cahill, Bertrand; Mikel, Lampard, Ramires; Oscar, Marin, Torres
Prague: Vaclik; Zapotocny, Hybs, Svejdik, Vacha; Matejovsky, Holek, Husbauer, Krejci; Bednar, Kadlec
Sports Mole says: 2-0