Despite being under intense pressure, Sarri is expected to heavily rotate his side for this trip to Scandinavia as it comes ahead of an FA Cup quarter-final against Manchester United.
A number of fringe players are pushing for inclusion, including Bayern Munich target Hudson-Odoi. The youngster missed a couple of training session last week through illness but should be fit in time for Thursday's match.
Cahill is the only other player carrying a slight knock, and Sarri will be keen to get the experienced centre-back into his side so that David Luiz and Antonio Rudiger can have the night off.
In fact, the entire backline could be different to the one that started against Man City, while Willy Caballero is in contention to replace Kepa Arrizabalaga in goal.
Sarri must decide which of his first-team regulars - if any - to call upon, with N'Golo Kante possibly being seen as an insurance policy in defensive midfield at the expense of Ethan Ampadu.
Elsewhere, Olivier Giroud - who has scored four goals in his last three Europa League games - should get the nod over Gonzalo Higuain through the middle.
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Who will win Thursday's Europa League tie between Malmo and Chelsea?