Shakhtar shocked the Blues with victory two weeks ago as they moved to the top of the group and with Juventus hosting Nordsjaelland on the same evening, three points is an absolute must for Roberto di Matteo's side.
Chelsea's form has dipped slightly after an impressive start to the season and they have lost two of their last five games in all competitions. Meanwhile, Shakhtar have won each of their last five matches and are considered by many as the dark horses for the tournament.
Chelsea are expected to have Juan Mata available after injury, while Fernando Torres and Oscar are also likely to start. Shakhtar, meanwhile, will look to Tottenham Hotspur target Willian to provide the inspiration after impressing last time out.
Chelsea: Cech; Ivanovic, Cahill, Luiz, Cole; Mikel, Ramires; Oscar, Mata, Hazard; Torres
Shakhtar: Pyatov; Rakitskiy, Srna, Kucher, Rat; Willian, Mkhitaryan, Ilisinho, Costa; Eduardo, Adriano
Sports Mole says: 1-1