The Spanish outfit need just two wins from their final three league games to secure the La Liga title this season.
"This is a very important meeting. From our team, only Tiago and [David] Villa have played in the Champions League semi-finals and we have a unique opportunity to get to the final. That being said, for us, this is the most important match of the season," he told AS.
"For us to say that this season has been spectacular, we need to finish well and these games that are coming up, which are the most important, we need to win them. What matters is how you finish, not how you start. We need to end the season with titles."
Atletico also reached the semi-final of the Copa del Rey this season, but were beaten by eventual winners Real Madrid.