The Bluebirds travel to the KC Stadium aware that Hull require a win to join them in the Premier League next season, and Mackay believes that his team must respect the situation put in front of them.
The 41-year-old told Wales Online: "We have to respect the League. This match is live on television and the outcome of matches on Sunday will mean £100m and more to one team.
"We have been top of the Championship for more than five months and we will do all we can to finish on a high."
Cardiff have already secured the Championship title, going into Sunday's match with an eight-point advantage over Hull.