However, with QPR not playing until Monday night, a win for Burnley would see them close the three-point gap and move into second by virtue of their superior goal difference.
To do that, they will have to end a run of three consecutive draws that have seen them drop six valuable points in recent weeks.
Sean Dyche's side have not lost in the league in 2014, however, and they could extend their unbeaten streak to seven matches on Saturday.
Burnley are the only remaining undefeated side at home in the Championship this season, while their tally of three defeats overall is also the best in the entire division.
At the other end of the table, Millwall are sitting perilously close to the relegation zone and could end the day in the bottom three if results go against them.
They are currently just two points from safety and would replace Charlton Athletic in the drop zone if they fail to win and the Addicks beat Birmingham City.
New manager Ian Holloway has made an inauspicious start to life in charge of the Lions, with one win, one draw and two defeats in his four matches at the helm.
One of his priorities in the aim to stay up will be to sort out his side's defence, which has leaked a league-high 54 goals in 28 matches so far this season.
Also on that priority list will be to improve the team's away form, which is the worst in the division as they have won just one match and managed seven points on the road.
Possible starting lineups
Burnley: Heaton; Trippier, Shackell, Duff, Mee; Jones, Marney, Arfield, Kightly; Ings, Vokes
Millwall: Bywater; Fredericks, Beevers, Shittu, Malone; Woolford, Williams, Upson, Feeney; Campbell, Morison
Sports Mole says: 3-0