The Mali international was taken off during half-time of the 5-2 defeat at Manchester City on Wednesday night because of a groin problem, which is not as bad as initially feared.
Leading scorer Danny Ings remains sidelined as he recovers from a leg injury, but is expected to be back after the international break.
Tariq Lamptey will have to undergo surgery for an ongoing hamstring problem, which is expected to see him absent for the remainder of the season.
Adam Webster has been continuing his return from an ankle injury at the start of February and is also targeting a return after the international break.
Southampton provisional squad: McCarthy, Bertrand, Vestergaard, Stephens, Salisu, Bednarek, Ward-Prowse, Redmond, Djenepo, Armstrong, Adams, Forster, Walker-Peters, Diallo, Ramsay, Watts, Minamino, Tella, N'Lundulu, Ferry
Brighton provisional squad: Sanchez, Veltman, White, Dunk, Burn, Gross, Bissouma, Mac Allister, Trossard, Lallana, Maupay, Moder, Jahanbakhsh, Alzate, Welbeck, Izquierdo, Tau, Steele, Propper, Zeqiri