The full-back returns following a knee injury to take a place on the right-hand side of a back four that also features Charlie Taylor - making his first Premier League start - on the opposite flank.
The hosts make four changes to the side that lost to Tottenham Hotspur on Wednesday as they try to prevent a fourth successive league defeat.
Brighton & Hove Albion: Ryan; Bruno, Duffy, Dunk, Bong; Propper, Stephens; Gross, March, Knockaert; Murray
Subs: Krul, Kayal, Hemed, Goldson, Izquierdo, Schelotto, Brown
Burnley: Pope; Bardsley, Mee, Tarkowski, Taylor; Gudmundsson, Cork, Defour, Arfield, Hendrick; Wood
Subs: Lowton, Vokes, Barnes, Westwood, Wells, Lindegaard, Long