Frank was able to name only five substitutes for the midweek Carabao Cup tie at Southampton, with several players self-isolating after an unnamed player from the B squad tested positive.
The Bees also made six changes to the side which lost at Birmingham on the opening day and they responded by beating a near full-strength Southampton 2-0.
Huddersfield forward Danny Ward is one of several players currently struggling with injury.
Ward, who rejoined Town in the summer, is not ready to return after missing the opening-day defeat to Norwich due to a hamstring problem.
Goalkeeper Ryan Schofield (thumb) and midfielder Lewis O'Brien (thigh) also remain unavailable.