The Dutch striker picked up a hamstring problem in Gladbach's midweek 2-2 draw with Hamburger SV.
De Jong told German publication Express: "I got a nasty kick on my foot against Hamburg.
"It hurts a lot. I do not know if I can play against Dortmund. It would be a shame if I could not play against Dortmund. It is an experience for any footballer."
Gladbach travel to Dortmund this weekend to face the reigning Bundesliga champions.