The visitors are currently in the relegation zone, having taken just six points from their opening 10 games in the division.
However, a win for Wednesday would see them escape the drop zone by leapfrogging Wanderers to send the hosts to 22nd in the league.
Bolton Wanderers: WDDLD
Sheffield Wednesday: DDLLD
Possible starting lineups
Bolton: Bogdan, McNaughton, Mills, Ream, Baptiste, Spearing, Medo, Pratley, Feeney, Danns, Beckford
Sheffield Weds: Kirkland, Llera, Johnson, Buxton, Johnson, McPhail, Coke, Antonio, Helan, Fryatt, Nuhui
Sports Mole says 1-0