The hosts are unbeaten in four games, but are still only five points clear of the relegation zone and one ahead of Wednesday.
The away side are in a similar position to Blackpool, just four points clear of the bottom three.
Sheffield Wednesday: LWWDWL
Possible starting lineups
Blackpool: Gilks; Crainey, Basham, Cathcart, Sylvestre; Phillips, Ferguson, Broadfoot, Baptiste, Ince, Delfouneso
Sheffield Wednesday: Kirkland; Buxton, Gardener, Llera, Pugh; Johnson, Prutton, Holden, Helan; McCabe, Lita
Sports Mole says: 2-1